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If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. Locoregional therapies, as imaging-guided tumor-directed procedures, are emerging treatment strategies in the management of primary and secondary liver malignancies such as e. As one of those, irradiation-based interstitial high dose rate brachytherapy iBT of liver metastases bears a risk of developing focal radiation-induced liver injury fRILI.
Since little is known about biological factors involved in hepatic dysfunction after irradiation, the aim of this study was to identify factors, that may play a role in the underlying mechanism of fRILI, and that potentially may serve as biomarkers for post-therapeutic fRILI to improve specific management and treatment of patients.
Twenty-two patients with hepatic malignancies tumor patients, TP underwent iBT with total ablative doses of radiation to the target volume ranging from e. Thus, investigation of biological mediators in blood samples from tumor patients may provide an appropriate tool to predict fRILI after interstitial HDR brachytherapy of liver metastases. Local-ablative therapies are emerging treatment options for primary and secondary liver malignancies such as hepatocellular carcinoma or colorectal cancer liver metastases Vogel et al.
In the last two decades, several techniques have been developed including thermal and irradiation-based ablation therapy, such as e. A common limitation of the liver-directed radiotherapy is radiation-induced liver disease RILD , often originating from sinusoidal obstruction syndrome SOS , formerly known as hepatic veno-occlusive disease VOD Fan and Crawford ; Bayraktar et al. Histopathological findings of RILD include deposits of extracellular matrix leading to a congestion of sinusoids and central veins with subsequent necrosis of hepatocytes Lawrence et al.
