To browse Academia. Skip to main content. Log In Sign Up. Followers Following Co-authors Public Views. Related Authors. Lesley Hall University College London. Zackary Berger Johns Hopkins University. Nathaniel Comfort Johns Hopkins University. Sunil Aggarwal University of Washington.
Hanna Kienzler King's College London. Fezal Ozdemir Ege University. Papers by Jochen Schubert. Breath analysis during one-lung ventilation in cancer patients. The European respiratory journal , Jan 20, Noninvasive breath analysis may provide valuable information for cancer recognition if disease-sp In order to compare nondiseased and diseased tissue in vivo, this study took advantage of the special circumstances of one-lung ventilation OLV during lung-surgery.
From each patient, alveolar breath samples were taken separately from healthy and diseased lungs before and after tumour resection.
Volatile substances were pre-concentrated by means of solid-phase microextraction, and were separated, identified and quantified by means of gas chromatography-mass spectrometry. Different classes of volatile substances could be identified according to their concentration profiles. Due to prolonged fasting and activation of lipolysis, concentrations of endogenous acetone significantly increased during surgery.
Exogenous substances, such as benzene or cyclohexanone, showed typical washout exhalation kinetics. Exhaled concentrations of potentially tumour associated substances, such as butane or pentane, were different for nondiseased and diseased lungs and decreased significantly after surgery.
